Structure of PDB 6pit Chain A

Receptor sequence
>6pitA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK
CVMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTTLKSLEEK
DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM
EHLYSMKVPLSDLLLEMLDAH
3D structure
PDB6pit Versatile Peptide Macrocyclization with Diels-Alder Cycloadditions.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST A L346 E353 L387 G521 H524 L525 L30 E37 L71 G199 H202 L203 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:6pit, PDBe:6pit, PDBj:6pit
PDBsum6pit
PubMed31523967
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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