Structure of PDB 6pib Chain A

Receptor sequence
>6pibA (length=245) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
VATLFIADLHLQTEEPAITAGFLRFLQGEARQADALYILGDLFEAWIGDD
DPNPLHQQIASAIKAVVDAGVPCYFIHGNRDFLVGQRFARQSGMILLAEE
ERLDLYGREVLIMHGDTLCTDDQGYLAFRAKVHTPWIQRLFLALPLFIRH
RIAARMRADSKAANSSKSMEIMDVNPQAVVDAMERHHVQWLIHGHTHRPA
VHELQANGQPAWRVVLGAWHSEGSMVKVTPDDVELIHFPFLLYFQ
3D structure
PDB6pib Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D8 H10 D41 H197 D8 H10 D41 H197
BS02 MN A D41 N79 H114 H195 D41 N79 H114 H195
BS03 OKV A A45 W46 N79 R80 F82 Y125 F128 I137 F141 A153 M156 R157 S160 A45 W46 N79 R80 F82 Y125 F128 I137 F141 A153 M156 R157 S160 MOAD: ic50=0.36uM
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pib, PDBe:6pib, PDBj:6pib
PDBsum6pib
PubMed32041866
UniProtA6T5R0|LPXH_KLEP7 UDP-2,3-diacylglucosamine hydrolase (Gene Name=lpxH)

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