Structure of PDB 6pia Chain A

Receptor sequence
>6piaA (length=345) Species: 1658765 (Marinobacter subterrani) [Search protein sequence]
GSMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQALGEI
LEPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGRGMR
ARLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEGERA
AFALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVDFHH
GNGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNLNIV
FPPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFKLTS
GDYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGKS
3D structure
PDB6pia Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani.
ChainA
Resolution1.75 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D195 H197 D284 D197 H199 D286
BS02 MG A D104 D106 D106 D108
BS03 XS6 A E17 L18 D19 D117 H158 H159 G167 Y168 D195 H197 F225 Y323 E19 L20 D21 D119 H160 H161 G169 Y170 D197 H199 F227 Y325 MOAD: ic50=550uM
PDBbind-CN: -logKd/Ki=4.96,Kd=11.0uM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006338 chromatin remodeling

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6pia, PDBe:6pia, PDBj:6pia
PDBsum6pia
PubMed31436969
UniProtA0A0J7JFD7

[Back to BioLiP]