Structure of PDB 6pi1 Chain A

Receptor sequence
>6pi1A (length=345) Species: 1658765 (Marinobacter subterrani) [Search protein sequence]
GSMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQALGEI
LEPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGRGMR
ARLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEGERA
AFALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVDFHH
GNGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNLNIV
FPPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFKLTS
GDYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGKS
3D structure
PDB6pi1 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D195 H197 D284 D197 H199 D286
BS02 MG A D104 D106 D106 D108
BS03 B3N A D19 D117 H158 H159 Y168 D195 H197 F225 I291 Y323 D21 D119 H160 H161 Y170 D197 H199 F227 I293 Y325 MOAD: ic50=160uM
PDBbind-CN: -logKd/Ki=3.80,IC50=160uM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006338 chromatin remodeling

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Molecular Function
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Biological Process
External links
PDB RCSB:6pi1, PDBe:6pi1, PDBj:6pi1
PDBsum6pi1
PubMed31436969
UniProtA0A0J7JFD7

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