Structure of PDB 6phz Chain A

Receptor sequence
>6phzA (length=347) Species: 1658765 (Marinobacter subterrani) [Search protein sequence]
GPLGSMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQAL
GEILEPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGR
GMRARLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEG
ERAAFALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVD
FHHGNGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNL
NIVFPPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFK
LTSGDYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGK
3D structure
PDB6phz Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D195 H197 D284 D200 H202 D289
BS02 MG A D104 D106 D109 D111
BS03 FKS A E17 L18 D19 D117 P156 H158 H159 G167 Y168 D195 H197 F225 G321 E22 L23 D24 D122 P161 H163 H164 G172 Y173 D200 H202 F230 G326 MOAD: ic50=350uM
PDBbind-CN: -logKd/Ki=3.46,IC50=350uM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006338 chromatin remodeling

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Molecular Function
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Biological Process
External links
PDB RCSB:6phz, PDBe:6phz, PDBj:6phz
PDBsum6phz
PubMed31436969
UniProtA0A0J7JFD7

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