Structure of PDB 6pht Chain A

Receptor sequence
>6phtA (length=346) Species: 1658765 (Marinobacter subterrani) [Search protein sequence]
LGSMKTVFSPLHSRRHVKTELDGGLLIEPHEKPSRAETILARVKDQALGE
ILEPEEFGLGPVKRVHTADYVSFLETCWDEWVAAGKRGEAIPTFWVGRGM
RARLPKDIDGRLGYYSLGADTSISDGTWEAARASANVALTAQKLVAEGER
AAFALCRPPGHHAHADVFGGYCFFNNAAIAAQAFRDQGYGKVAVLDVDFH
HGNGTQAIFYDRSDVLTISLHGDPDLVFPHFLGFEDETGEGDGEAYNLNI
VFPPDTPFSIWSQGLEKACERIRTFAPDALVVALGVDTFEEDPISFFKLT
SGDYLKLGKRLEQLGLPTVFTMEGGYDVDAIGVNAVNVMQGFEGKS
3D structure
PDB6pht Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OKP A H158 H159 G167 Y168 D195 H197 F225 D284 Y323 H161 H162 G170 Y171 D198 H200 F228 D287 Y326 MOAD: ic50=390uM
PDBbind-CN: -logKd/Ki=3.41,IC50=390uM
BS02 MG A D104 D106 D107 D109
BS03 ZN A D195 H197 D284 D198 H200 D287
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006338 chromatin remodeling

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6pht, PDBe:6pht, PDBj:6pht
PDBsum6pht
PubMed31436969
UniProtA0A0J7JFD7

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