Structure of PDB 6ph9 Chain A

Receptor sequence
>6ph9A (length=243) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
MVATLFIADLHLQTEEPAITAGFLRFLQGEARQADALYILGDLFEAWIGD
DDPNPLHQQIASAIKAVVDAGVPCYFIHGNRDFLVGQRFARQSGMILLAE
EERLDLYGREVLIMHGDTLCTDDQGYLAFRAKVHTPWIQRLFLALPLFIR
HRIAARMRADSKAANSSKSMEIMDVNPQAVVDAMERHHVQWLIHGHTHRP
AVHELQANGQPAWRVVLGAWHSEGSMVKVTPDDVELIHFPFLE
3D structure
PDB6ph9 Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.
ChainA
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D8 H10 D41 H197 L241 E242 D9 H11 D42 H198 L242 E243
BS02 MN A D41 N79 H114 H195 D42 N80 H115 H196
BS03 LP5 A N79 R80 F82 L83 Y125 F128 F141 M156 R157 S160 N164 K167 H195 N80 R81 F83 L84 Y126 F129 F142 M157 R158 S161 N165 K168 H196
BS04 CA A E170 D173 E171 D174
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6ph9, PDBe:6ph9, PDBj:6ph9
PDBsum6ph9
PubMed32041866
UniProtA6T5R0|LPXH_KLEP7 UDP-2,3-diacylglucosamine hydrolase (Gene Name=lpxH)

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