Structure of PDB 6pgr Chain A

Receptor sequence
>6pgrA (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
ALAAVLKHSSESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQV
NAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETI
RYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRI
GNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINN
PESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLI
NTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSD
SGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFM
3D structure
PDB6pgr Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8XY A Y103 T104 V129 I266 N267 I280 V286 H288 K329 Y87 T88 V113 I250 N251 I264 V270 H272 K313 MOAD: ic50=0.062uM
BindingDB: IC50=56000nM
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0046203 spermidine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pgr, PDBe:6pgr, PDBj:6pgr
PDBsum6pgr
PubMed32142284
UniProtP49366|DHYS_HUMAN Deoxyhypusine synthase (Gene Name=DHPS)

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