Structure of PDB 6pfm Chain A

Receptor sequence
>6pfmA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKC
3D structure
PDB6pfm Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
ChainA
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OGJ A L346 A350 D351 L387 L391 F404 M421 G521 H524 L525 L40 A44 D45 L81 L85 F98 M115 G215 H218 L219 BindingDB: IC50=0.030000nM
External links
PDB RCSB:6pfm, PDBe:6pfm, PDBj:6pfm
PDBsum6pfm
PubMed31311734
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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