Structure of PDB 6pf1 Chain A

Receptor sequence
>6pf1A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQGSKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHAS
DKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQ
EYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLG
YTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWFKKMLDKAVSERI
VHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKESSQKLYATME
KHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHL
EFSSLRRAQWSTMCMLVELHTQ
3D structure
PDB6pf1 Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.
ChainA
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A L1398 S1400 R1410 T1411 Y1414 Y1446 K1456 I1457 P1458 R1462 L1463 W1466 L119 S121 R131 T132 Y135 Y167 K177 I178 P179 R183 L184 W187 BindingDB: IC50=45940nM
BS02 OJ7 A H1434 I1435 I1486 A1490 L1501 P1502 D1507 W1509 F1595 F1596 H155 I156 I207 A211 L222 P223 D228 W230 F256 F257 MOAD: ic50=39uM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6pf1, PDBe:6pf1, PDBj:6pf1
PDBsum6pf1
PubMed31649965
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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