Structure of PDB 6pdj Chain A

Receptor sequence
>6pdjA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLK
QGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVD
FLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTL
SCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSF
GILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLC
WKERPEDRPTFDYLRSVLEDFFTA
3D structure
PDB6pdj Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.
ChainA
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D364 A368 N369 D382
Catalytic site (residue number reindexed from 1) D138 A142 N143 D156
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ODJ A L251 A271 K273 M280 F285 N290 I314 T316 Y318 M319 G322 L371 D382 F383 G384 L25 A45 K47 M54 F59 N64 I88 T90 Y92 M93 G96 L145 D156 F157 G158 PDBbind-CN: -logKd/Ki=7.38,IC50=42nM
BindingDB: IC50=42nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6pdj, PDBe:6pdj, PDBj:6pdj
PDBsum6pdj
PubMed31620238
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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