Structure of PDB 6pau Chain A

Receptor sequence

>6pauA (length=361) Species: 9606 (Homo sapiens)

GAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDD
NMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRI
YDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGV
VLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKT
SGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTF
VVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLM
SDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPG
TDSEKVGLVLQ

3D structure

• PDB: 6pau NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.
• Chain: A
• Resolution: 1.93 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y180 V181 D183 D185 M187 F188 R189 F190 T282 G284 Y296 H298 F311 S312 H313 I469 G470 D471 G472 L474	Y45 V46 D48 D50 M52 F53 R54 F55 T147 G149 Y161 H163 F176 S177 H178 I334 G335 D336 G337 L339
BS02	MG	A	R255 S256 K257 V259	R120 S121 K122 V124
BS03	4PS	A	V181 L248 C249 V250 R255 S256 R258 A260 P261	V46 L113 C114 V115 R120 S121 R123 A125 P126

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity

Biological Process

• GO:0006499 N-terminal protein myristoylation

External links

• PDB: RCSB:6pau, PDBe:6pau, PDBj:6pau
• PDBsum: 6pau
• PubMed: 32103017
• UniProt: O60551|NMT2_HUMAN Glycylpeptide N-tetradecanoyltransferase 2 (Gene Name=NMT2)