Structure of PDB 6p9b Chain A

Receptor sequence

>6p9bA (length=99) Species: 11686 (Human immunodeficiency virus type 1 (BRU ISOLATE))

PQITLWKRPIITIKIGGQLKDVLMDTGADDTVLENIDLPGKWKPKLIGGI
GGFVKVRQYDHVPVEVAGHKVTTTVLVGPTPVDVIGRNLLTQIGATLNF

3D structure

• PDB: 6p9b Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
• Chain: A
• Resolution: 1.75 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D25 T26 G27
• Catalytic site (residue number reindexed from 1): D25 T26 G27
• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	478	A	D25 G27 A28 D30 G49 I50 V82	D25 G27 A28 D30 G49 I50 V82	MOAD: Ki=3.6nM

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6p9b, PDBe:6p9b, PDBj:6p9b
• PDBsum: 6p9b
• PubMed: 31920003
• UniProt: P03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)