Structure of PDB 6p9a Chain A

Receptor sequence
>6p9aA (length=99) Species: 11686 (Human immunodeficiency virus type 1 (BRU ISOLATE)) [Search protein sequence]
PQITLWKRPIITIKIGGQLKDVLMDTGADDTVLENIDLPGKWKPKLIGGI
GGFVKVRQYDHVPVEVAGHKVTTTVLVGPTPVDVIGRNLLTQIGATLNF
3D structure
PDB6p9a Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
ChainA
Resolution1.66 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 017 A D25 G27 A28 D29 D30 G48 I50 V82 D25 G27 A28 D29 D30 G48 I50 V82 MOAD: Ki=4nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6p9a, PDBe:6p9a, PDBj:6p9a
PDBsum6p9a
PubMed31920003
UniProtP03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)

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