Structure of PDB 6p98 Chain A

Receptor sequence
>6p98A (length=245) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
VAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPAS
TFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVV
PVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQI
SFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIG
WWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP
3D structure
PDB6p98 Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S118 Y123 W157 Y211
Catalytic site (residue number reindexed from 1) S50 K53 S98 Y103 W137 Y191
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KE1 A S70 V120 T209 G210 Y211 R250 S50 V100 T189 G190 Y191 R230
BS02 CA A E37 H38 E256 E17 H18 E236
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6p98, PDBe:6p98, PDBj:6p98
PDBsum6p98
PubMed31358584
UniProtQ6XEC0

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