Structure of PDB 6p8y Chain A

Receptor sequence
>6p8yA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
SLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKH
3D structure
PDB6p8y Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 Y32 N116 K117 D119 L120 S145 A146 G13 V14 G15 K16 S17 A18 Y32 N116 K117 D119 L120 S145 A146
BS02 O5Y A C12 K16 P34 A59 R68 M72 H95 Y96 Q99 C12 K16 P34 A59 R68 M72 H95 Y96 Q99 PDBbind-CN: -logKd/Ki=6.20,IC50=0.638uM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6p8y, PDBe:6p8y, PDBj:6p8y
PDBsum6p8y
PubMed31531201
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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