Structure of PDB 6p8q Chain A

Receptor sequence

>6p8qA (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]

PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR
EATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCL
LDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP
QHVKITDFGLAKLLGVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTF
GSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDV
VDADEYLIP

3D structure

PDB

6p8q Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.

Chain

Resolution

1.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D837 R841 N842 D855
Catalytic site (residue number reindexed from 1)	D139 R143 N144 D157
Enzyme Commision number	2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ANP	A	L718 G719 G721 A722 V726 A743 M790 M793 C797 D837 R841 N842 L844 D855	L20 G21 G23 A24 V28 A45 M92 M95 C99 D139 R143 N144 L146 D157
BS02	O57	A	A743 K745 M766 C775 L788 M790 D855 F856 L858 L861	A45 K47 M68 C77 L90 M92 D157 F158 L160 L163
BS03	MG	A	G721 F723 K745	G23 F25 K47
BS04	MG	A	N842 D855	N144 D157

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6p8q, PDBe:6p8q, PDBj:6p8q
PDBsum	6p8q
PubMed	31749909
UniProt	P00533\|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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