Structure of PDB 6p7u Chain A

Receptor sequence
>6p7uA (length=426) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
LDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGT
VMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVG
QVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVSGV
CHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRR
AYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLR
LGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRR
GAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVA
VMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGV
VDEKIDPAHTRSKLTEALAQAPARRG
3D structure
PDB6p7u Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis
ChainA
Resolution2.198 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A99 G137 G138 Y326 G366 A367
Catalytic site (residue number reindexed from 1) A87 G125 G126 Y286 G326 A327
Enzyme Commision number 2.1.3.-
2.1.3.15: acetyl-CoA carboxytransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FTJ A F115 G137 G138 Y141 F103 G125 G126 Y129
BS02 FTJ A L295 Y326 G341 L345 G366 I369 L255 Y286 G301 L305 G326 I329
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0004658 propionyl-CoA carboxylase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016874 ligase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0019367 fatty acid elongation, saturated fatty acid
Cellular Component
GO:0009274 peptidoglycan-based cell wall
GO:0009317 acetyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6p7u, PDBe:6p7u, PDBj:6p7u
PDBsum6p7u
PubMed
UniProtP9WQH5|ACCD6_MYCTU Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta6 subunit (Gene Name=accD6)

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