Structure of PDB 6p6v Chain A

Receptor sequence
>6p6vA (length=193) Species: 356390 (Hepatitis C virus SA13) [Search protein sequence]
GSVAIVGRIILSGDTAYAQQTRGEEGAQEVSQTGRDKNEAEGEVQVLSTA
TQTFLGTCINGVMWTVFHGAGAKTLAGPKGPVVQMYTNVDKDLVGWPTPP
GTRSLTPCTCGSADLYLVTRHADVVPARRRGDTRASLLSPRPISYLKGSS
GGPVMCPSGHVVGVFRAAVCTRGVAKALDFIPVENLETTMRSP
3D structure
PDB6p6v Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences
ChainA
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 H1149 C108 C110 C156 H160
BS02 O31 A Q1041 H1057 D1081 R1123 I1132 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 D1168 Q52 H68 D92 R134 I143 L146 K147 G148 S150 F165 R166 A167 A168 D179
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6p6v, PDBe:6p6v, PDBj:6p6v
PDBsum6p6v
PubMed
UniProtO91936|POLG_HCVSA Genome polyprotein

[Back to BioLiP]