Structure of PDB 6p6t Chain A

Receptor sequence
>6p6tA (length=159) Species: 356418 (Hepatitis C virus ED43) [Search protein sequence]
GSVVIVGRVVLGEVQVLSTATQSFLGTAVNGVMWSVYHGAGGKTISGPKG
PVNQMYTNVDQDLVGWPAPPGVKSLTPCTCGASDLYLVTRHADVVPVRRR
GDTRGALLSPRPISTLKGSSGGPLLCPMGHVAGLFRAAVCTRGVAKAVDF
VPVESLETT
3D structure
PDB6p6t Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 C78 C80 C126
BS02 O31 A Q1041 Y1056 H1057 V1078 D1081 R1123 I1132 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 D1168 Q22 Y37 H38 V59 D62 R104 I113 L116 K117 G118 S120 F135 R136 A137 A138 D149
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6p6t, PDBe:6p6t, PDBj:6p6t
PDBsum6p6t
PubMed
UniProtO39929|POLG_HCVED Genome polyprotein

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