Structure of PDB 6p6r Chain A

Receptor sequence
>6p6rA (length=201) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]
SHMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVE
GEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDK
DLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSTGSLLSPR
PLSYLKGSSGGPLLCPAGHAVGIFRAAVSTRGVAKAVQFIPVESLETTMR
S
3D structure
PDB6p6r Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences
ChainA
Resolution1.749 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 H1149 C117 C119 C165 H169
BS02 O31 A Q1041 F1043 H1057 D1081 L1132 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 Q1168 Q61 F63 H77 D101 L152 L155 K156 G157 S159 F174 R175 A176 A177 Q188
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6p6r, PDBe:6p6r, PDBj:6p6r
PDBsum6p6r
PubMed
UniProtP26664|POLG_HCV1 Genome polyprotein

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