Structure of PDB 6p6q Chain A

Receptor sequence
>6p6qA (length=197) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]
MASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGE
VQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDL
VGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSTGSLLSPRPL
SYLKGSSGGPLLCPAGHAVGIFRAAVSTRGVAKAVQFIPVESLETTM
3D structure
PDB6p6q Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SUE A Q1041 F1043 H1057 V1078 D1081 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 Q1168 Q59 F61 H75 V96 D99 L153 K154 G155 S157 F172 R173 A174 A175 Q186
BS02 ZN A C1097 C1145 C115 C163
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6p6q, PDBe:6p6q, PDBj:6p6q
PDBsum6p6q
PubMed
UniProtP26664|POLG_HCV1 Genome polyprotein

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