Structure of PDB 6p6m Chain A

Receptor sequence
>6p6mA (length=201) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]
GSHMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQV
EGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVD
KDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSP
RPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVESLETTM
R
3D structure
PDB6p6m HCV NS3/4A protease domain of genotype 1a in complex with glecaprevir
ChainA
Resolution2.201 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O31 A Q1041 F1043 H1057 D1081 R1123 I1132 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 D1168 Q62 F64 H78 D102 R144 I153 L156 K157 G158 S160 F175 R176 A177 A178 D189
BS02 ZN A C1097 C1099 C1145 C118 C120 C166
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6p6m, PDBe:6p6m, PDBj:6p6m
PDBsum6p6m
PubMed
UniProtP26664|POLG_HCV1 Genome polyprotein

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