Structure of PDB 6p6l Chain A

Receptor sequence
>6p6lA (length=200) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]
GSHMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQV
EGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVD
KDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSP
RPISYLKGSSGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTM
3D structure
PDB6p6l HCV NS3/4A protease domain of genotype 1a in complex with glecaprevir
ChainA
Resolution1.728 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 S1139
Catalytic site (residue number reindexed from 1) H78 D102 G158 S160
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1097 C1099 C1145 H1149 C118 C120 C166 H170
BS02 O31 A Q1041 H1057 D1081 R1123 L1135 K1136 G1137 S1139 F1154 R1155 A1156 A1157 D1168 Q62 H78 D102 R144 L156 K157 G158 S160 F175 R176 A177 A178 D189
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6p6l, PDBe:6p6l, PDBj:6p6l
PDBsum6p6l
PubMed
UniProtP26664|POLG_HCV1 Genome polyprotein

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