Structure of PDB 6p69 Chain A

Receptor sequence
>6p69A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
EYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLPNRVTKVAVKM
LKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVECAS
KGNLREYLQARRPPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR
NVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIY
THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTN
ELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE
3D structure
PDB6p69 To be published
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 A625 R627 N628 D641
Catalytic site (residue number reindexed from 1) D146 A148 R150 N151 D164
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O21 A L484 E486 G487 V492 L494 K514 E531 M535 I545 V561 C563 A564 S565 L630 A640 D641 L23 E25 G26 V31 L33 K49 E66 M70 I80 V96 C98 A99 S100 L153 A163 D164 BindingDB: IC50=1020nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6p69, PDBe:6p69, PDBj:6p69
PDBsum6p69
PubMed
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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