Structure of PDB 6p5s Chain A

Receptor sequence
>6p5sA (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
QLVQHEVLCSMTNTYEVLEFLGRGQVVKCWKRGTNEIVAIKILRQGQIEV
SILARLSTESADDYNFVRAYECFQHHTCLVFEMLEQNLYDFLKQNKFSPL
PLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVID
FGSASHVTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYP
GASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPD
DHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFID
LLKKMLTIDADKRITPIETLNHPFVTMTHLLDF
3D structure
PDB6p5s The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
ChainA
Resolution2.194 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D324 K326 N329 D346 S364
Catalytic site (residue number reindexed from 1) D128 K130 N133 D150 S162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3NG A G206 R207 K228 F277 M279 L280 M331 I345 D346 G22 R23 K41 F81 M83 L84 M135 I149 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6p5s, PDBe:6p5s, PDBj:6p5s
PDBsum6p5s
PubMed31341017
UniProtQ9H2X6|HIPK2_HUMAN Homeodomain-interacting protein kinase 2 (Gene Name=HIPK2)

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