Structure of PDB 6p3d Chain A

Receptor sequence
>6p3dA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
KMDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQL
QAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASE
TKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDF
GLATESGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSN
INNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFP
RILAEIEELARELS
3D structure
PDB6p3d Inhibitors of BRAF dimers using an allosteric site.
ChainA
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D131 K133 N135 N136 D149 S158
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A A481 K483 E501 L514 I527 T529 W531 C532 I573 H574 F583 G593 D594 F595 A36 K38 E56 L69 I82 T84 W86 C87 I128 H129 F138 G148 D149 F150 MOAD: ic50=14nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6p3d, PDBe:6p3d, PDBj:6p3d
PDBsum6p3d
PubMed32873792
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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