Structure of PDB 6p2j Chain A

Receptor sequence
>6p2jA (length=408) Species: 9606 (Homo sapiens) [Search protein sequence]
EQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGR
LVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHP
LIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMK
AHSFVRENVPRVLNSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWG
YVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSIL
PGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWN
VVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFF
YPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQE
WYARQHCP
3D structure
PDB6p2j Structural basis for catalysis and substrate specificity of human ACAT1.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.26: sterol O-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3VV A W407 N415 Y417 W420 Y429 Y433 K445 F453 H460 W286 N294 Y296 W299 Y308 Y312 K324 F332 H339
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0004772 sterol O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0015485 cholesterol binding
GO:0016746 acyltransferase activity
GO:0034736 cholesterol O-acyltransferase activity
Biological Process
GO:0008203 cholesterol metabolic process
GO:0010742 macrophage derived foam cell differentiation
GO:0010878 cholesterol storage
GO:0033344 cholesterol efflux
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034383 low-density lipoprotein particle clearance
GO:0042632 cholesterol homeostasis
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6p2j, PDBe:6p2j, PDBj:6p2j
PDBsum6p2j
PubMed32433614
UniProtP35610|SOAT1_HUMAN Sterol O-acyltransferase 1 (Gene Name=SOAT1)

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