Structure of PDB 6p26 Chain A

Receptor sequence
>6p26A (length=241) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence]
LAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDD
YHNFDALNIPGHHPARADHDTFWFDTTRLLRTQTSGVQIRTMKAQQPPIR
IIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFE
EDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGID
PEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK
3D structure
PDB6p26 Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
ChainA
Resolution3.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NO4 A L143 E210 F248 F250 G271 C272 V275 A294 F295 L57 E124 F162 F164 G185 C186 V189 A208 F209
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6p26, PDBe:6p26, PDBj:6p26
PDBsum6p26
PubMed33411531
UniProtP08312|SYFA_ECOLI Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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