Structure of PDB 6p25 Chain A

Receptor sequence

>6p25A (length=731) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence]

PVPELDIKQGPVRPFIVTDPSAELASLRTMVTLKEKLLVACLAVFTAVIR
LHGLAWPDSVVFDEVHFGGFASQYIRGTYFMDVHPPLAKMLYAGVASLGG
FQGDFDFENIGDSFPSTTPYVLMRFFSASLGALTVILMYMTLRYSGVRMW
VALMSAICFAVENSYVTISRYILLDAPLMFFIAAAVYSFKKYEMYPANSL
NAYKSLLATGIALGMASSSKWVGLFTVTWVGLLCIWRLWFMIGDLTKSSK
SIFKVAFAKLAFLLGVPFALYLVFFYIHFQSLTLDGDGASFFSPEFRSTL
KNNKIPQNVVADVGIGSIISLRHLSTMGGYLHSHSHNYPAGSEQQQSTLY
PHMDANNDWLLELYNSLTTFQNLTDGTKVRLFHTVTRCRLHSHDHKPPVS
ESSDWQKEVSCYGYSGFDGDANDDWVVEIDKKNSAPGVAQERVIALDTKF
RLRHAMTGCYLFSHEVKLPAWGFEQQEVTCASSGRHDLTLWYVENNSNPL
LPEDTKRISYKPASFISKFIESHKKMWHINKNLVEPHVYESQPTSWPFLL
RGISYWGENNRNVYLLGNAIVWWAVTAFIGIFGLIVITELFSWQLGKPIL
KDSKVVNFHVQVIHYLLGFAVHYAPSFLMQRQMFLHHYLPAYYFGILALG
HALDIIVSYVFRSKRQMGYAVVITFLAASVYFFKSFSPIIYGTPWTQELC
QKSQWLSGWDYNCNTYFSSLEEYKNQTLTKR

3D structure

PDB

6p25 Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.109: dolichyl-phosphate-mannose--protein mannosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CPL	A	P565 G598 F600 I631 L634 Y641 A642 F645	P547 G580 F582 I613 L616 Y623 A624 F627
BS02	NNM	A	H98 K234 W235 L238 F239 T242 G245 A270 L274 L277 L278 W545 N548 M647 R649 H655	H84 K220 W221 L224 F225 T228 G231 A256 L260 L263 L264 W527 N530 M629 R631 H637
BS03	CPL	A	I256 S263 F267	I242 S249 F253

Gene Ontology

	Molecular Function
GO:0000030	mannosyltransferase activity
GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0005515	protein binding
GO:0016757	glycosyltransferase activity

	Biological Process
GO:0006486	protein glycosylation
GO:0006493	protein O-linked glycosylation
GO:0009272	fungal-type cell wall biogenesis
GO:0032527	protein exit from endoplasmic reticulum
GO:0035269	protein O-linked mannosylation
GO:0036503	ERAD pathway
GO:1900101	regulation of endoplasmic reticulum unfolded protein response

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0097582	dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex
GO:0097583	dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6p25, PDBe:6p25, PDBj:6p25
PDBsum	6p25
PubMed	31285605
UniProt	P33775\|PMT1_YEAST Dolichyl-phosphate-mannose--protein mannosyltransferase 1 (Gene Name=PMT1)

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