Structure of PDB 6p14 Chain A

Receptor sequence
>6p14A (length=265) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
VVSVKEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRP
ELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISKLVRALFA
VARHMQPSIIFIDEVDSLRLKTEFLVEFDGDRIVVLAATNRPQELDEAAL
RRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGS
DLAALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVA
PQSLNSYEKWSQDYG
3D structure
PDB6p14 Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.
ChainA
Resolution1.93001 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NKY A A486 Q488 N527 L531 S649 L650 P651 L659 G688 S689 A30 Q32 N71 L75 S160 L161 P162 L170 G199 S200 MOAD: ic50=0.22uM
PDBbind-CN: -logKd/Ki=6.66,IC50=0.22uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6p14, PDBe:6p14, PDBj:6p14
PDBsum6p14
PubMed31257183
UniProtQ8I0P1|SPAST_DROME Spastin (Gene Name=spas)

[Back to BioLiP]