Structure of PDB 6p0e Chain A

Receptor sequence

>6p0eA (length=642) Species: 9606 (Homo sapiens) [Search protein sequence]

SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFR
DIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSV
LAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCE
VPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFE
EAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIK
LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYA
FDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAE
FLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDL
VVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHH
QSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAAR
GLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS

3D structure

PDB

6p0e Two-tiered enforcement of high-fidelity DNA ligation.

Chain

Resolution

1.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	G348 V349 G350 G352 V353 Q572 R573 S588 R589 N590 F635 F872	G89 V90 G91 G93 V94 Q313 R314 S329 R330 N331 F376 F613
BS02	dna	A	S303 R549 K744 K746 Y749 T798 G799 F800 S801 D802 F872 R874	S44 R290 K485 K487 Y490 T539 G540 F541 S542 D543 F613 R615
BS03	dna	A	R305 T415 G416 S417 A418 T420 R451 G453 A455 Q457 S458 T639 T640 R641 K642 R643 R738 G767 R768 G769 K770 G776 K795 G797 S850 L851 S852 P853 Y855 S869 L870	R46 T156 G157 S158 A159 T161 R192 G194 A196 Q198 S199 T380 T381 R382 K383 R384 R479 G508 R509 G510 K511 G517 K536 G538 S591 L592 S593 P594 Y596 S610 L611
BS04	AMP	A	K568 Y569 R573 E621 F660 M723 K725 W742 K744	K309 Y310 R314 E362 F401 M464 K466 W483 K485

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6p0e, PDBe:6p0e, PDBj:6p0e
PDBsum	6p0e
PubMed	31780661
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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