Structure of PDB 6p0a Chain A

Receptor sequence

>6p0aA (length=639) Species: 9606 (Homo sapiens) [Search protein sequence]

SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSQRLMLPPPPLTASGVFSKFRDIA
RLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAA
LSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPD
LDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAA
FTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPS
VTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDL
IYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLE
QSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVI
GAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSL
KALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLV
DSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS

3D structure

PDB

6p0a Two-tiered enforcement of high-fidelity DNA ligation.

Chain

Resolution

2.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E346 G348 V349 G350 G571 Q572 S588 R589 E592 F635 F872	E87 G89 V90 G91 G309 Q310 S326 R327 E330 F373 F610
BS02	dna	A	S303 R589 K744 Y749 T798 G799 F800 S801 D802 F872 R874	S44 R327 K482 Y487 T536 G537 F538 S539 D540 F610 R612
BS03	dna	A	R305 G416 A418 T420 R451 G453 A455 Q457 S458 H546 T639 R641 K642 R643 R738 R768 G769 K770 G776 K795 G797 S850 L851 S852 P853 Y855 S869 L870 F872	R46 G154 A156 T158 R189 G191 A193 Q195 S196 H284 T377 R379 K380 R381 R476 R506 G507 K508 G514 K533 G535 S588 L589 S590 P591 Y593 S607 L608 F610
BS04	AMP	A	Y567 K568 Y569 R573 E621 F660 M723 K725 K744	Y305 K306 Y307 R311 E359 F398 M461 K463 K482

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6p0a, PDBe:6p0a, PDBj:6p0a
PDBsum	6p0a
PubMed	31780661
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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