Structure of PDB 6p07 Chain A

Receptor sequence
>6p07A (length=270) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
GVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILKGLLLFGP
PGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHM
QPSIIFIDQVDSLLSERSSSEHEASRRLKTEFLVEFDGDRIVVLAATNRP
QELDEAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAK
ITDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITEQDFHSSL
KRIRRSVAPQSLNSYEKWSQ
3D structure
PDB6p07 An allosteric network in spastin couples multiple activities required for microtubule severing.
ChainA
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K555 Y556 V557 S594 K81 Y82 V83 S120
BS02 ATP A A486 N527 G528 K529 T530 L531 N629 L659 S689 A27 N53 G54 K55 T56 L57 N148 L178 S208
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6p07, PDBe:6p07, PDBj:6p07
PDBsum6p07
PubMed31285604
UniProtA0A0B4LHJ5

[Back to BioLiP]