Structure of PDB 6p00 Chain A

Receptor sequence
>6p00A (length=518) Species: 68170 (Lentzea aerocolonigenes) [Search protein sequence]
SGKIDKILIVGGGTAGWMAASYLGKALQGTADITLLQAPDIPTLGVGEAT
MPNLQTAFFDFLGIPEDEWMRECNASYKVAIKFINWRTAGEGTSEARELD
GGPDHFYHPFGLLKYHEQIPLSHYWFDRLYRGKTVEPFDYACYKEPVILD
ANRSPRRLDGSKVTSYAWHFDAHLVADFLRRFATEKLGVRHVEDRVEHVQ
RDANGNIESVRTATGRVFDADLFVDCSGFRGLLINKAMEEPFLDMSDHLL
NDSAVATQVPHDDDANGVEPFTSAIAMKSGWTWKIPMLGRFGTGYVYSSR
FATEDEAVREFCEMWHLDPETQPLNRIRFRVGRNRRAWVGNCVSIGTSSC
FVEPLESTGIYFVYAALYQLVKHFPDKSFNPVLTARFNREIETMFDDTRD
FIQAHFYFSPRTDTPFWRANKELRLADGMQEKIDMYRAGMAINAPANFEE
EFRNLWNNSSYYCVLAGLGLVPDAPSPRLAHMPRATESVDEVFGAVKDQQ
RNLLETLPSLHEFLRQQH
3D structure
PDB6p00 Structural and Computational Analysis of Laboratory-Evolved Halogenases Reveals Molecular Details of Site-Selectivity
ChainA
Resolution2.249 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.19.9: tryptophan 7-halogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G13 A16 L37 A39 E49 A50 R196 V197 S228 L233 T348 P355 G360 I361 G12 A15 L36 A38 E48 A49 R195 V196 S227 L232 T347 P354 G359 I360
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6p00, PDBe:6p00, PDBj:6p00
PDBsum6p00
PubMed
UniProtQ8KHZ8|TRP7H_LENAE Tryptophan 7-halogenase RebH (Gene Name=rebH)

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