Structure of PDB 6ozs Chain A

Receptor sequence

>6ozsA (length=244) Species: 10090 (Mus musculus)

AERPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSGLQKVGGVDVSF
VKVRACASLVVLSYPELKVVYEDSRMVGLKAPYVSGFLAFREVPFLVELV
QRLQEKEPDLMPQVVLVDGNGVLHQRGFGVACHLGVLTELPCIGVAKKLL
QVDGLENNALHKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTKPLY
VSVGHRISLEVAVRLTHHCCRFRIPEPIRQADIRSREYIRRTLG

3D structure

• PDB: 6ozs Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.
• Chain: A
• Resolution: 2.41 Å

Enzymatic activity

• Enzyme Commision number: 3.1.26.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Y91 S93 G94 L96 E100 D126 N128 H132 Q133 V138 K155 K156 L158 Q159	Y83 S85 G86 L88 E92 D118 N120 H124 Q125 V130 K147 K148 L150 Q151
BS02	rna	A	D52 S54 F55 D126 K155 R244	D47 S49 F50 D118 K147 R236
BS03	rna	A	K156 H202 S203 T204 K205 F230 R231 R237 R244 R248	K148 H194 S195 T196 K197 F222 R223 R229 R236 R240
BS04	MG	A	D52 D240	D47 D232
BS05	MG	A	D52 D126	D47 D118

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6ozs, PDBe:6ozs, PDBj:6ozs
• PDBsum: 6ozs
• PubMed: 31444105
• UniProt: Q8C9A2|ENDOV_MOUSE Endonuclease V (Gene Name=Endov)