Structure of PDB 6ozp Chain A

Receptor sequence

>6ozpA (length=244) Species: 10090 (Mus musculus)

RPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSGLQKVGGVDVSFVK
DSVRACASLVVLSYPELKVVYEDSRMVGLKAPYVSGFLAFREVPFLVELV
QRLQEKEPDLMPQVVLVDGNGVLHQRGFGVACHLGVLTELPCIGVAKKLL
QVDGLENNALHKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTKPLY
VSVGHRISLEVAVRLTHHCCRFRIPEPIRQADIRSREYIRRTLG

3D structure

• PDB: 6ozp Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.
• Chain: A
• Resolution: 1.96 Å

Enzymatic activity

• Enzyme Commision number: 3.1.26.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Y91 S93 G94 L96 E100 D126 N128 H132 Q133 G137 V138 K155 K156 L158 Q159	Y83 S85 G86 L88 E92 D118 N120 H124 Q125 G129 V130 K147 K148 L150 Q151
BS02	rna	A	D52 S54 F55 D126 K155	D45 S47 F48 D118 K147
BS03	rna	A	H202 S203 T204 K205 F230 R231 R237 R244 R248	H194 S195 T196 K197 F222 R223 R229 R236 R240
BS04	MN	A	D52 D240	D45 D232
BS05	MN	A	D52 D126	D45 D118

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6ozp, PDBe:6ozp, PDBj:6ozp
• PDBsum: 6ozp
• PubMed: 31444105
• UniProt: Q8C9A2|ENDOV_MOUSE Endonuclease V (Gene Name=Endov)