Structure of PDB 6oyz Chain A

Receptor sequence
>6oyzA (length=313) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
YITFRSFTAVLIAFFLTLVLSPSFINRLRKIQRKKYTPTMGGIVILIVVT
LSTLLLMRWDIKYTWVVLLSFLSFGTIGFWDDYVKLKNKKGISIKTKFLL
QVLSASLISVLIYYWADIDTILYFPFFKELYVDLGVLYLPFAVFVIVGSA
NAVNLTDGLDGLAIGPAMTTATALGVVAYAVGHSKIAQYLNIPYVPYAGE
LTVFCFALVGAGLGFLWFNSFPAQMFMGDVGSLSIGASLATVALLTKSEF
IFAVAAGVFVFETISVILQIIYFRWTPFHHHLELNGLPEPKIVVRMWIIS
ILLAIIAISMLKL
3D structure
PDB6oyz Chemical logic of MraY inhibition by antibacterial nucleoside natural products.
ChainA
Resolution3.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.13: phospho-N-acetylmuramoyl-pentapeptide-transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NKM A K70 T75 K121 D193 G194 L195 D196 F262 M263 G264 K34 T39 K85 D157 G158 L159 D160 F226 M227 G228 PDBbind-CN: -logKd/Ki=6.73,IC50=185nM
Gene Ontology
Molecular Function
GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051992 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0044038 cell wall macromolecule biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6oyz, PDBe:6oyz, PDBj:6oyz
PDBsum6oyz
PubMed31266949
UniProtO66465|MRAY_AQUAE Phospho-N-acetylmuramoyl-pentapeptide-transferase (Gene Name=mraY)

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