Structure of PDB 6oyw Chain A

Receptor sequence
>6oywA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
LEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKW
GPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKI
SDFGTSKRLCTEEFTGTLQYMAPEIIDKGYGKAADIWSLGCTIIEMATGK
PPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRAC
ANDLLVDEFLK
3D structure
PDB6oyw Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.
ChainA
Resolution2.603 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D133 K135 D137 N138 D152 T167
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NKJ A L686 K709 M754 E755 Q756 V757 G760 L810 S821 D822 L16 K39 M84 E85 Q86 V87 G90 L140 S151 D152 BindingDB: IC50=4.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6oyw, PDBe:6oyw, PDBj:6oyw
PDBsum6oyw
PubMed31710475
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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