Structure of PDB 6oyt Chain A

Receptor sequence
>6oytA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
MESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKW
GPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKI
SDFGTSKRLGKAADIWSLGCTIIEMATGKPPVHPEIPESMSAEAKAFILK
CFEPDPDKRACANDLLVDEFLK
3D structure
PDB6oyt Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.
ChainA
Resolution2.824 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822
Catalytic site (residue number reindexed from 1) D133 K135 D137 N138 D152
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NJV A L686 G687 V694 A707 K709 M754 E755 Q756 V757 G759 G760 L810 D822 L21 G22 V29 A42 K44 M84 E85 Q86 V87 G89 G90 L140 D152 PDBbind-CN: -logKd/Ki=8.23,IC50=5.9nM
BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6oyt, PDBe:6oyt, PDBj:6oyt
PDBsum6oyt
PubMed31710475
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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