Structure of PDB 6ox0 Chain A

Receptor sequence

>6ox0A (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVT
FDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF
LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNS
FWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYF
YKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLAL
IPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAE
FVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFAL
HFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSW
DNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLG
EKEILEKAVKSAAVNREYYRQQMEEKAPLPK

3D structure

PDB

6ox0 Structural basis for the target specificity of actin histidine methyltransferase SETD3.

Chain

Resolution

1.755 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.85: protein-histidine N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	M151 N153 I154 N211 Q254 N255 Q256 P258 W273 D274 I283 T285 G286 Y287 C294 Y312 R315	M132 N134 I135 N192 Q235 N236 Q237 P239 W254 D255 I264 T266 G267 Y268 C275 Y293 R296
BS02	SFG	A	R74 E103 F105 R253 D274 M275 N277 H278 Y312 S324 F326	R55 E84 F86 R234 D255 M256 N258 H259 Y293 S305 F307	PDBbind-CN: -logKd/Ki=4.85,Ki=14uM

Gene Ontology

	Molecular Function
GO:0003713	transcription coactivator activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016279	protein-lysine N-methyltransferase activity
GO:0018064	protein-L-histidine N-tele-methyltransferase activity
GO:0042800	histone H3K4 methyltransferase activity
GO:0046975	histone H3K36 methyltransferase activity
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding

	Biological Process
GO:0006338	chromatin remodeling
GO:0018021	peptidyl-histidine methylation
GO:0018023	peptidyl-lysine trimethylation
GO:0030047	actin modification
GO:0032259	methylation
GO:0045893	positive regulation of DNA-templated transcription
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0051149	positive regulation of muscle cell differentiation
GO:0070472	regulation of uterine smooth muscle contraction

	Cellular Component
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6ox0, PDBe:6ox0, PDBj:6ox0
PDBsum	6ox0
PubMed	31388018
UniProt	Q86TU7\|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)

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