Structure of PDB 6ovc Chain A

Receptor sequence
>6ovcA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
MEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDG
VQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLIS
FGAFVAKHLKTINQESSIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFF
HVEDLEGGHHHHHH
3D structure
PDB6ovc AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N8J A H55 M62 V84 R94 T97 L98 F101 H55 M62 V84 R94 T97 L98 F101 PDBbind-CN: -logKd/Ki=6.52,IC50=0.3uM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6ovc, PDBe:6ovc, PDBj:6ovc
PDBsum6ovc
PubMed30254093
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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