Structure of PDB 6ova Chain A

Receptor sequence
>6ovaA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKSGWK
QEIDILRTLYHEHIIKYKGCCESLQLVMEYVPLGSLRDYLPRHSIGLAQL
LLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPE
GHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDS
SQSPPTKFLELIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCW
ETEASFRPTFENLIPILKTVHEK
3D structure
PDB6ova Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) N123 A125 R127 N128 D141 P164
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N9G A L903 G906 V911 I960 V981 P982 G984 N1028 D1041 L16 G19 V24 I65 V81 P82 G84 N128 D141 MOAD: ic50=1.1nM
BindingDB: IC50=1.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ova, PDBe:6ova, PDBj:6ova
PDBsum6ova
PubMed31980341
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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