Structure of PDB 6ouw Chain A

Receptor sequence
>6ouwA (length=544) Species: 1299 (Deinococcus radiodurans) [Search protein sequence]
TSDTPLLDQIHGPKDLKRLSREQLPALTEELRGEIVRVCSRGGLHLASSL
GAVDIITALHYVLDSPRDRILFDVGHQAYAHKILTGRRDQMADIKKEGGI
SGFTKVSESEHDAITVGHASTSLANALGMALARDAQGKDFHVAAVIGDGS
LTGGMALAALNTIGDMGRKMLIVLNDNEMPFAAMGVRYVGPVDGHNVQEL
VWLLERLVDLDGPTILHIVTTKGKAKFDPATGEYVPSSAYSWSAAFGEAV
TEWAKTDPRTFVVTPAMREGSGLVEFSRVHPHRYLDVGIAEEVAVTTAAG
MALQGMRPVVAIYSTFLQRAYDQVLHDVAIEHLNVTFCIDRAGIVGADGA
THNGVFDLSFLRSIPGVRIGLPKDAAELRGMLKYAQTHDGPFAIRYPRGN
TAQVPAGTWPDLKWGEWERLKGGDDVVILAGGKALDYALKAAEDLPGVGV
VNARFVKPLDEEMLREVGGRARALITVEDNTVVGGFGGAVLEALNSMNLH
PTVRVLGIPDEFQEHATAESVHARAGIDAPAIRTVLAELGVDVP
3D structure
PDB6ouw X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.
ChainA
Resolution2.398 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K289 E373 R401
Catalytic site (residue number reindexed from 1) K222 E291 R319
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HTL A H51 S54 H82 H124 A125 G153 D154 G155 S156 N183 K289 I371 E373 F398 R401 H45 S48 H76 H118 A119 G147 D148 G149 S150 N177 K222 I289 E291 F316 R319
BS02 MG A D154 N183 D148 N177
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
GO:0016740 transferase activity
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0009228 thiamine biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0052865 1-deoxy-D-xylulose 5-phosphate biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6ouw, PDBe:6ouw, PDBj:6ouw
PDBsum6ouw
PubMed31239351
UniProtQ9RUB5|DXS_DEIRA 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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