Structure of PDB 6otj Chain A

Receptor sequence
>6otjA (length=427) Species: 521006 (Neisseria gonorrhoeae NCCP11945) [Search protein sequence]
MSVIQDLQSRGLIAQTTDIEALDALLNEQKIALYCGFDPTADSLHIGHLL
PVLALRRFQQAGHTPIALVGGATGMIGDPSFKAAERSLNSAETVAGWVGS
IRSQLTPFLSFEGGNAAIMANNADWFGSMNCLDFLRDIGKHFSVNAMLNK
ESVKQRIDRDGAGISFTEFAYSLLQGYDFAELNKRHGAVLEIGGSDQWGN
ITAGIDLTRRLNQKQVFGLTLPLVTKSDGTKFGKTEGGAVWLNAKKTSPY
QFYQFWLKVADADVYKFLKYFTFLSIEEIGVVEAKDKASGSKPEAQRILA
EEMTRLIHGEEALAAAQRISESLFAEDQSRLTESDFEQLALDGLPAFEVS
DGINAVEALVKTGLAASNKEARGFVNAKAVLLNGKPAEANNPNHPDDAYL
LIGEYKRFGKYTILRRGKRNHALLVWK
3D structure
PDB6otj Crystal Structure of Tyrosyl-tRNA synthetase from Neisseria gonorrhoeae with bound L-Tyr
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T40 H45 H48 K82 R86 Q175 D196 K231 K234 T235
Catalytic site (residue number reindexed from 1) T40 H45 H48 K82 R86 Q175 D196 K231 K234 T235
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR A Y34 G36 D38 L68 D78 Y171 Q175 D178 Q197 Y34 G36 D38 L68 D78 Y171 Q175 D178 Q197
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6otj, PDBe:6otj, PDBj:6otj
PDBsum6otj
PubMed
UniProtB4RP13|SYY_NEIG2 Tyrosine--tRNA ligase (Gene Name=tyrS)

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