Structure of PDB 6or1 Chain A

Receptor sequence
>6or1A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
SIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHLSTFGLMCKMADQ
TLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEG
SIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCL
KFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLL
RLPEIRAISMQAEEYLYYKHLNGDVNNLLIEMLHA
3D structure
PDB6or1 Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
ChainA
Resolution2.174 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F354 R361 D372 M375 Q379 L531 E534 M535 F53 R60 D71 M74 Q78 L228 E231 M232
BS02 N27 A F342 M345 C346 M348 H390 L405 L427 L517 F41 M44 C45 M47 H89 L104 L126 L216 BindingDB: EC50=13000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:6or1, PDBe:6or1, PDBj:6or1
PDBsum6or1
PubMed31419141
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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