Structure of PDB 6oqy Chain A

Receptor sequence
>6oqyA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
SIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHESTFGLMCKMADQ
TLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEG
SIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCL
KFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLL
RLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHA
3D structure
PDB6oqy Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F354 R361 V371 Q374 M375 L531 E534 F53 R60 V70 Q73 M74 L230 E233
BS02 N2J A M345 C346 M348 I387 H390 L405 V406 A420 L427 M428 L517 M44 C45 M47 I86 H89 L104 V105 A119 L126 M127 L216 BindingDB: EC50=600nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:6oqy, PDBe:6oqy, PDBj:6oqy
PDBsum6oqy
PubMed31419141
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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