Structure of PDB 6oqo Chain A

Receptor sequence
>6oqoA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGGMPLSTIREV
AVLRHLETFEHPNVVRLFDVCTVKLTLVFEHVDQDLTTYLDKVPEPGVPT
ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAVT
LWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL
DVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLT
FNPAKRISAYSALSHPYFQ
3D structure
PDB6oqo Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
ChainA
Resolution1.977 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D145 K147 Q149 N150 D163 T182
Catalytic site (residue number reindexed from 1) D126 K128 Q130 N131 D144 T150
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N1J A I19 Y24 A41 V101 Q149 L152 D163 I9 Y14 A31 V82 Q130 L133 D144 BindingDB: Ki=2.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0042127 regulation of cell population proliferation
GO:0043697 cell dedifferentiation

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Molecular Function
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Biological Process
External links
PDB RCSB:6oqo, PDBe:6oqo, PDBj:6oqo
PDBsum6oqo
PubMed31307887
UniProtQ00534|CDK6_HUMAN Cyclin-dependent kinase 6 (Gene Name=CDK6)

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