Structure of PDB 6oqc Chain A

Receptor sequence
>6oqcA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
VE
3D structure
PDB6oqc AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N0S A H224 A227 F228 V249 M250 V253 R263 T266 L267 F270 H54 A57 F58 V79 M80 V83 R93 T96 L97 F100 MOAD: Ki=0.00005uM
PDBbind-CN: -logKd/Ki=10.40,Ki=0.04nM
BindingDB: Ki=0.040000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6oqc, PDBe:6oqc, PDBj:6oqc
PDBsum6oqc
PubMed30254093
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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