Structure of PDB 6oqb Chain A

Receptor sequence
>6oqbA (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
EDLEG
3D structure
PDB6oqb AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
ChainA
Resolution1.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N0J A H224 A227 V249 M250 V253 F254 R263 T266 L267 F270 I294 H53 A56 V78 M79 V82 F83 R92 T95 L96 F99 I123 MOAD: Ki=0.00004uM
PDBbind-CN: -logKd/Ki=10.30,Ki=0.05nM
BindingDB: Ki=0.050000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6oqb, PDBe:6oqb, PDBj:6oqb
PDBsum6oqb
PubMed30254093
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

[Back to BioLiP]